The Developmental Synaptopathies Consortium (DSC) Administrative Unit will facilitate the collaboration and communication of clinical research in the rare diseases of TSC, PTEN and PMS across the ten participating sites. The Administrative Unit will ensure collaboration among Project Leaders, Principal Investigators, and site study staff for the longitudinal research in each of the three identified diseases, the training component, the clinical pilot studies, and the access to information related to the rare diseases for basic and clinical researchers, other health professionals and the public.